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目的研究吡柔比星(THP)对非肌层浸润性膀胱癌早期定位诊断的可行性。方法选择已诊断膀胱癌或高度怀疑尿路上皮癌的31例患者。予患者术前及术后复查时,30 mgTHP溶入5%葡萄糖液50 mL中,灌入已排空的膀胱中,保留15 min,排出THP,彻底冲洗膀胱。再次普通膀胱镜检查,有THP吸收的非肿瘤区域取活检,无THP吸收的部位随机活检。结果 31患者中存在非肌层浸润性膀胱癌早期者共5例。结论 THP对非肌层浸润性膀胱癌早期的定位诊断明确,安全性好。
Objective To study the feasibility of pirarubicin (THP) in early diagnosis of non-muscle invasive bladder cancer. Methods Thirty-one patients with diagnosed bladder cancer or highly suspected urothelial cancer were enrolled. To patients preoperative and postoperative review, 30 mgTHP dissolved in 5% glucose solution 50 mL, was poured into the bladder has been emptied, retained 15 min, the discharge of THP, thoroughly washed the bladder. Again common cystoscopy, non-tumor area with THP to take biopsy, no THP absorption of the site of random biopsy. Results There were 5 cases of early non-muscle invasive bladder cancer in 31 patients. Conclusions THP has a clear and early diagnosis of non-muscle invasive bladder cancer with good safety.