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[目的]探讨糖化血红蛋白(HbA1c)、空腹血糖(FBG)及纤维蛋白原(FIB)在糖尿病(DM)监测中的意义。[方法]对146例糖耐量正常者、165例糖尿病患者(DM组)进行HbA1c、FPG、2hPG及FIB的测定,并对结果进行对比分析。[结果]糖尿病组HbA1c、FPG、2hPG及FIB水平明显高于正常对照组,差异均具有统计学意义(P﹤0.01)。[结论]检测糖化血红蛋白能较好地反映血糖控制水平,对糖尿病的诊断、控制和预防有重要的临床应用价值,糖化血红蛋白和血糖有良好的相关性。FIB水平显著上升说明糖尿病患者的血液高凝程度加剧,有血栓形成的危险,应予以重视。
[Objective] To investigate the significance of glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG) and fibrinogen (FIB) in the monitoring of diabetes mellitus (DM). [Method] The determination of HbA1c, FPG, 2hPG and FIB in 146 patients with normal glucose tolerance and 165 diabetes mellitus (DM group) was carried out. The results were compared and analyzed. [Results] The levels of HbA1c, FPG, 2hPG and FIB in diabetic group were significantly higher than those in normal control group, with statistical significance (P <0.01). [Conclusion] The detection of HbA1c can better reflect the level of blood sugar control. It has important clinical value for the diagnosis, control and prevention of diabetes. The HbA1c and blood sugar have a good correlation. The significant increase of FIB level indicates that the degree of hypercoagulability of blood in patients with diabetes is aggravating and the risk of thrombosis should be taken seriously.