论文部分内容阅读
目的分析脑原发淋巴瘤的临床特点,探讨其治疗方式。方法8例脑原发淋巴瘤中7例行手术切除,1例行立体定向活检。8例均行放射治疗,1例接受γ刀治疗,7例6MV X线常规分割照射,全脑照射30～46 Gy,病灶区剂量40～56 Gy。6例接受了化疗,行CHOP方案4例,大剂量甲氨蝶呤(MTX)为主的化疗2例,鞘注MTX 3例。结果患者近期疗效好,全组生存时间为8～47个月,中位生存期19个月。1、3年生存率分别为75.0%和31.3%。加化疗未延长生存期,予MTX化疗者生存时间较长。结论脑原发淋巴瘤预后差,全脑放疗为主要治疗方式之一,放疗与MTX为主的化疗方案的综合治疗有可能提高疗效。
Objective To analyze the clinical features of primary brain lymphoma and to explore its treatment. Methods Eight cases of primary brain lymphoma were treated by surgical resection and one case was treated by stereotactic biopsy. Radiotherapy was performed in 8 cases, γ knife in 1 case, conventional radiography in 7 cases with 6MV X-ray, whole brain irradiation in 30 ~ 46 Gy, and dose in the lesion ranged from 40 Gy to 56 Gy. Of the 6 patients who received chemotherapy, there were 4 CHOP regimens, 2 methotrexate (MTX) -based chemotherapy and 3 intrathecal injection of MTX. The results of patients with good short-term effect, the whole group survival time was 8 to 47 months, the median survival of 19 months. The 1-year and 3-year survival rates were 75.0% and 31.3% respectively. Chemotherapy did not extend the survival period, to MTX chemotherapy longer survival time. Conclusions The prognosis of brain primary lymphoma is poor and whole brain radiation therapy is one of the main treatments. The combination of radiotherapy and MTX-based chemotherapy may improve the curative effect.