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目的:探究盐酸右美托咪啶对中老年食管癌患者麻醉苏醒期心血管反应的预防作用。方法:选取84例中老年食管癌患者将其分为A组(麻醉后给予适当盐酸右美托咪啶)及B组(对照组),比较其血流动力学变化情况。结果:两组患者手术结束后MAP、Sp O2及HR水平组间比较均无明显差异(P>0.05),拔管前、后及拔管后5 min,B组患者MAP、HR水平均明显高于A组,至拔管后10 min,两组患者MAP、Sp O2及HR水平均有所下降,但相关指标B组仍高于A组(P<0.05)。结论:术后给予中老年食管癌患者盐酸右美托咪啶,可预防或减弱该患者麻醉后苏醒期的心血管反应,对中老年患者平稳度过麻醉后苏醒期具有一定益处。
Objective: To investigate the preventive effect of dexmedetomidine hydrochloride on the cardiovascular response during anesthesia and awakening in middle-aged and elderly patients with esophageal cancer. Methods: Eighty-four elderly patients with esophageal cancer were divided into group A (dexmedetomidine hydrochloride given after anesthesia) and group B (control group), and their hemodynamic changes were compared. Results: There were no significant differences in MAP, Sp O2 and HR between the two groups after operation (P> 0.05). The levels of MAP and HR in group B were significantly higher before and after extubation and 5 min after extubation In group A, the levels of MAP, Sp O2 and HR decreased in both groups 10 minutes after extubation, but the related indexes in group B were still higher than those in group A (P <0.05). Conclusion: Dexmedetomidine given to patients with esophageal cancer in the middle-aged and elderly patients can prevent or reduce the cardiovascular response during anesthesia during anesthesia, and has some benefits in the wake-up period of middle-aged and elderly patients after stable anesthesia.