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目的:探讨多囊卵巢综合征(PCOS)患者血清自身抗体水平。方法:选择就诊于该院的PCOS患者35例为研究组,非PCOS患者35例为对照组,间接免疫荧光法(IIF)检测抗核抗体(ANA)、线性免疫印迹法(LIA)检测血清抗组蛋白抗体、抗Sm抗体、抗双链DNA抗体、抗核小体抗体水平。结果:PCOS患者血清抗组蛋白抗体、抗双链DNA抗体与对照组存在统计学差异,抗核抗体、抗Sm抗体、抗核小体抗体无统计学差异。结论:PCOS患者存在血清自身抗体阳性,自身免疫可能涉及PCOS发病或疾病进展。
Objective: To investigate the level of serum autoantibodies in patients with polycystic ovary syndrome (PCOS). Methods: Thirty-five patients with PCOS were selected as study group, 35 patients with non-PCOS as control group, ANA by indirect immunofluorescence assay (LNA), serum anti-nuclear antibody Histone antibodies, anti-Sm antibodies, anti-double-stranded DNA antibodies, anti-nucleosome antibody levels. Results: Serum anti-histone antibody and anti-double-stranded DNA antibody in PCOS patients were significantly different from those in control group. There was no significant difference in antinuclear antibody, anti-Sm antibody and anti-nucleosome antibody. Conclusion: Serum autoantibodies are present in patients with PCOS. Autoimmunity may be related to the pathogenesis of PCOS or disease progression.