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为探讨P物质与药源性震颤麻痹综合症的关系。采用放射免疫法测定了使用神经阻滞剂后无药源性震颤麻痹综合症精神分裂症病人21例（A组）和有药源性震颤麻痹综合症精神分裂症病人40例（B组）血浆中P物质（SP）含量。结果A组的血浆中SP含量（7．4±3．79Pg／ml）明显低于B组（10．08±2．89Pg／ml），两组比较有显著性差异（P＜0．01），在BPRS得分、病程、发病次数上，两组比较均无显著性差异（P＞0．05）。结果表明，神经阻滞剂所致药源性震颤麻痹综合症可能与精神分裂症血浆SP的增高有关，与精神病性症状、病程及发病次数无关。
To explore the relationship between substance P and drug-induced Parkinsonism paralysis. 21 patients with schizophrenia without drug-induced tremor syndrome (group A) and 40 patients with schizophrenia with drug-induced tremor paralysis (group B) were measured by radioimmunoassay In substance P (SP) content. Results The plasma SP content in group A (7.4 ± 3.79Pg / ml) was significantly lower than that in group B (10.08 ± 2.89Pg / ml), with significant difference between the two groups (P <0.01) There was no significant difference between the two groups in the scores of BPRS, the course of disease and the frequency of onset (P> 0.05). The results showed that drug-induced paralysis syndrome caused by nerve blockers may be related to schizophrenia with increased plasma SP, with no correlation with psychotic symptoms, duration and frequency of onset.