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新喋呤(neopterin)是由激活的T 细胞分泌γ-干扰素刺激单核/巨噬细胞释放而来,由肾小球滤过,系细胞介导免疫激活的标志。作者用放免法测定129例单株峰丙种球蛋白异常症患者中血清新噪呤浓度。包括未明原因单株峰丙种球蛋白异常症(MGUS)56例,多发性骨髓瘤(MM)73例(其中诊断时测定新喋呤浓度63倒,缓解时58例,复发时35例),血清肌酐值<1.2mg/d1 者列入本研究。70例健康人为正常对照。正常对照、MGUS 和MM 患者的中数新喋呤浓度分别为5.3(范围2—8.6)、6.8(范围2.9—26)和10.7(范围3—131.8)nmol/L,MM 和MGUS
Neopterin is a marker released by activated T cells to secrete γ-interferon to stimulate monocytes / macrophages to glomerular filtration and to mediate immune activation. The authors used radioimmunoassay to determine the serum neo-nontremia in 129 patients with monoclonal IgG. Including 56 patients with unexplained plant tropomyosus abnormality (MGUS), 73 with multiple myeloma (MM with 63 downtime at diagnosis, 58 with remission, and 35 with relapse), serum Creatinine value <1.2mg / d1 were included in this study. 70 healthy people as normal control. The median neopterin concentrations of MGUS and MM patients were 5.3 (range 2-8.6), 6.8 (range 2.9-26) and 10.7 (range 3-131.8) nmol / L, respectively, for MM and MGUS