论文部分内容阅读
建立了一种简单、快速、能同时测定复方甲硝唑片中甲硝唑与维生素B6的方法.采用0.100mol/LNaOH和2.0%的四硼酸钠溶液为介质,测定波长为288和320nm.维生素B6的存在不干扰甲硝唑的直接测定.赋形剂对该测定方法不干扰.甲硝唑的回收率为96.6%~102.0%,RSD为1.6%~3.8%;维生素B6的回收率为95.2%~106.3%,RSD为5.4%~8.1%.该方法简单、成本低、易于操作.
A simple and rapid method was established for the simultaneous determination of metronidazole and vitamin B6 in compound metronidazole tablets with wavelength of 288 and 320 nm using 0.100 mol / L NaOH and 2.0% sodium tetraborate solution as the mediators. The presence of B6 did not interfere with the direct determination of metronidazole.Excipients did not interfere with this assay.The recoveries of metronidazole ranged from 96.6% to 102.0% with a RSD of 1.6% to 3.8% and the recovery of vitamin B6 was 95.2 % ~ 106.3%, RSD 5.4% ~ 8.1% .The method is simple, low cost and easy to operate.