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目的:探讨荔枝核对小鼠肿瘤动物模型及其免疫调节作用的实验研究。方法:移植性肝癌与S1801∶1肿瘤组织生理盐水混悬液,每只小鼠腋窝皮下接种肝癌、S180肿瘤细胞悬液。24h后,灌胃给药,1次/天,连续10d。检测肝癌的抑瘤作用和S180荷瘤小鼠的免疫功能。结果:荔枝核高(62g/kg)、低(31g/kg)剂量均能显著抑制肝癌生长和升高S180荷瘤小鼠血清IgG抗体水平,对2,4-二硝基氟苯诱导的迟发性超敏反应有增强作用;能诱导淋巴细胞转化为淋巴母细胞;提高小鼠网状内皮系统的碳粒廓清;促进PHA(植物血球凝集素);并能增强小鼠红细胞免疫功能。结论:荔枝核对小鼠肝癌和S180荷瘤生长具有抑制作用;并能显著增强荷瘤小鼠S180的细胞免疫功能。
Objective: To explore the experimental study of Litchi nucleus on animal models of mouse tumor and its immune regulation. METHODS: Transplanted hepatocellular carcinoma and S1801:1 tumor tissue normal saline suspension. Each mouse was inoculated subcutaneously with liver cancer and S180 tumor cell suspension. After 24 hours, intragastric administration was performed once daily for 10 days. The anti-tumor effect of liver cancer and the immune function of S180 tumor-bearing mice were examined. RESULTS: Both litchi high (62 g/kg) and low (31 g/kg) doses significantly inhibited the growth of hepatocellular carcinoma and elevated serum IgG antibody levels in S180 tumor-bearing mice, and delayed the induction of 2,4-dinitrofluorobenzene. The hypersensitivity reaction has a potentiating effect; lymphocytes can be induced to transform into lymphoblasts; carbon granule clearance of mouse reticuloendothelial system is increased; PHA (phytohaemagglutinin) is promoted; and mouse erythrocyte immune function can be enhanced. Conclusion: Litchi nucleus inhibits the growth of hepatocellular carcinoma and S180 tumor in mice, and can significantly enhance the cellular immunity of tumor-bearing mice S180.