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目的 :为了解稻皮黄单胞菌在院内感染中的分布及耐药趋势。方法 :对 1997年 1月～ 1999年 6月住院及门诊患者的痰、中段尿、伤口分泌物等标本 ,进行细菌学培养、鉴定 ,并通过WHONET系统进行数据分析。结果 :分离出 5 0株稻皮黄单胞菌对 2 4种抗生素药敏结果显示 ,亚胺培南、丁胺卡那、头孢他啶、环丙沙星和妥布霉素耐药率分别为 14% ,2 2 % ,2 6 % ,32 % ,36 %。对亚胺培南耐药的稻皮黄单胞菌对其它抗生素的耐药率要明显高于亚胺培南敏感株。对丁胺卡那与亚胺培南、头孢他啶、哌拉西林、环丙沙星、妥布霉素进行散点图配对分析 ,发现组合之间有一定的互补性。结论 :稻皮黄单胞菌感染有逐年上升的趋势 ,治疗该菌引起的感染性疾病最为有效的抗生素是亚胺培南、头孢他啶和丁胺卡那。耐亚胺培南的稻皮黄单胞菌更应引起临床医生的注意。
Objective: To understand the distribution and drug resistance trend of Xanthomonas oryzae in nosocomial infection. Methods: The specimens of sputum, middle urine and wound secretions of inpatients and outpatients from January 1997 to June 1999 were cultured, identified and analyzed by WHONET system. Results: The results of drug susceptibility tests of 50 strains of X. anisopliae to 24 antibiotics showed that the resistance rates of imipenem, amikacin, ceftazidime, ciprofloxacin and tobramycin were 14% , 2 2%, 26%, 32%, 36%. The resistant rates of imipenem-resistant Xanthomonas oryzae to other antibiotics were significantly higher than those of imipenem-susceptible strains. The amikacin and imipenem, ceftazidime, piperacillin, ciprofloxacin, tobramycin scatter plot paired analysis, found that there is a certain complementarity between the combination. Conclusion: The infection of Xanthomonas oryzae has a trend of increasing year by year. The most effective antibiotics for infecting infectious diseases caused by this bacterium are imipenem, ceftazidime and amikacin. Imipenem-resistant Enterobacter aerogenes should arouse the attention of clinicians.