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用免疫组织化学法和图像分析法研究了党参和维生素E对大鼠下丘脑室周核生长抑素神经元的增龄性变化的影响.实验结果表明:3、10、24月龄对照鼠生长抑素神经元的灰度与胞体截面积随增龄而增加(P<0.05),细胞数则随增龄而减少(P<0.05).而喂食党参与维生素E的动物,从3～10月龄,其灰度、胞体截面积及细胞数呈增龄性升高.且明显高于同龄对照组(P<0.05).从10月龄喂药至24月龄鼠.其生长抑素神经元的灰度无明显增龄性变化(P>0.05),但明显低于同龄对照组;胞体截面积轻度减少(P>0.05),也明显低于同龄对照组;细胞数呈增龄性减少(P<0.05),但明显高于同龄对照组.为党参和维生素E参与抗衰老提供了一些形态学的证据.
The effects of Codonopsis pilosula and Vitamin E on the age-related changes of somatostatin neurons in rat periventricular nucleus were studied by immunohistochemistry and image analysis. The results showed that the control rats grew at 3, 10, and 24 months of age. The grayscale and cell body cross-sectional area of somatostatin neurons increase with age (P<0.05), while the number of cells decreases with age (P<0.05). Feeding the party’s participation in vitamin E animals, from March to October At the age, the gray scale, cell body cross-sectional area, and cell number increased with age, and it was significantly higher than that of the same age control group (P<0.05). The somatostatin neurons were fed from 10 months of age to 24 months old. There was no significant age change in the gray scale (P>0.05), but it was significantly lower than that of the same age control group; the cell body cross-sectional area was slightly reduced (P>0.05), and it was also significantly lower than that of the same age control group; the number of cells showed a decrease in age. (P<0.05), but significantly higher than that of the same age control group. It provides some morphological evidence for the participation of Codonopsis and Vitamin E in anti-aging.