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PURPOSE: To introduce a case of POEMS (polyneuropa- thy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) sy ndrome with bilateral cystoid macular edema (CME). DESIGN: Interventional case r eport. METHODS: Temporal changes of serum vascular endothelial growth factor (VE GF) levels and macular thickness were evaluated. RESULTS: A 53-year-old woman with POEMS syndrome was referred complaining of long-standing impaired vision. Typical CME demonstrating petal-like dye pooling was observed in both eyes. Aft er subtenon administrations of triamcinolone acetonide (TA), pars plana vitrecto my, and intraocular TA injection in the right eye, macular thickness decreased. Intraocular VEGF levels were < 31 pg/ml at the vitrectomy and intraocular TA inj ection, whereas serum the VEGF level was >2000 pg/ml throughout the follow-up periods. In the untreated left eye, macular th ickness altered related to serum VEGF level. CONCLUSIONS: Based on the low intra ocular VEGF level and serum VEGF-related change of macular thickness, elevated serum VEGF might be a cause of CME in POEMS syndrome.
PURPOSE: To introduce a case of POEMS (polyneuropa- thy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome with bilateral cystoid macular edema (CME). METHODS: Interventional case r eport. METHODS: Temporal changes of serum vascular endothelial growth factor (VE GF) levels and macular thickness were evaluated. RESULTS: A 53-year-old woman with POEMS syndrome was referred complaining of long-standing impaired vision. A CME demonstrating petal-like dye pooling was observed in both eyes. Aft er subtenon administrations of triamcinolone acetonide (TA), pars plana vitrecto my, and intraocular TA injection in the right eye, macular thickness decreased. Intraocular VEGF levels were <31 pg / ml at the vitrectomy and intraocular TA inj ection, level was> 2000 pg / ml throughout the follow-up periods. In the untreated left eye, macular thickness related related to serum VEGF level. CONCLUSIONS: Based on the low intra ocular VEGF level and serum VEGF-related change of macular thickness, elevated serum VEGF might be a cause of CME in POEMS syndrome.