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本文对1976年～1996年间在British Columbia诊治的117例HCL的患者进行了前瞻性随访,以了解继发肿瘤的发生情况。 结果:117例HCL中男90例,女27例,中位年龄53岁,中位随访时间68个月,23例行脾切除术,65例以IFN-α疗,24例接受脱氧助间型霉素(deoxycoformglin,DCF)治疗,67例以2-氯脱氧腺苷(cladribine,z-CDA)治疗。36例患者发生其它恶性肿瘤(30.7％),共计44种肿瘤。6例除HCL外发生2种或2种以上恶性肿瘤(5.1％)。25例(21.3％)肿瘤发生于HCL之后,3例(2.6％)与HCL并发;12例(10.2％)发生于HCL之前;HCL之后发生的中位时间为40个月(3～167),其中前列腺癌7例,非黑色素皮肤癌9例,肺癌2例,胃肠道腺癌4例,11例患者的
This article prospectively followed 117 patients with HCL diagnosed in British Columbia between 1976 and 1996 to understand the occurrence of secondary tumors. Results: Of the 117 cases of HCL, 90 were males and 27 were females. The median age was 53 years. The median follow-up time was 68 months. Splenectomy was performed in 23 cases, 65 cases were treated with IFN-alpha, and 24 cases received deoxygenation. Treated with deoxycoformglin (DCF), 67 patients were treated with 2-chlorodeoxy-adenosine (z-CDA). Thirty-six patients developed other malignancies (30.7%) and a total of 44 tumors. Two or more malignancies (5.1%) occurred in 6 patients except HCL. Twenty-five (21.3%) tumors occurred after HCL, 3 (2.6%) were complicated by HCL, 12 (10.2%) occurred before HCL, and the median time after HCL was 40 months (3 to 167). Among them, there were 7 cases of prostate cancer, 9 cases of non-melanoma skin cancer, 2 cases of lung cancer, 4 cases of gastrointestinal adenocarcinoma, and 11 cases of