血管紧张素Ⅱ的大部分心血管效应(如收缩血管、升血压、刺激醛固酮分泌、促进心肌和血管细胞增殖等)是由血管紧张素Ⅱ-1型受体(AT1)介导,但是越来越多的实验结果显示:血管紧张素Ⅱ-2型受体(AT2)具有拮抗AT1的功能,起着对抗细胞生长和心肌肥厚及促细胞分化、凋亡,扩张血管,降低血压等作用,并认为其可能是一种潜在的心脏、血管保护性受体。现就近年来对AT在心脏保护方面的研究进展作一综述。 Most of the cardiovascular effects of angiotensin II (such as contracting blood vessels, raising blood pressure, stimulating aldosterone secretion, promoting myocardial and vascular cell proliferation, etc.) are mediated by angiotensin Ⅱ type 1 receptor (AT1) The more experimental results show that AT2 can antagonize the function of AT1, play an antagonistic role in cell growth and cardiac hypertrophy and promote cell differentiation, apoptosis, dilate blood vessels and lower blood pressure, etc. Think it may be a potential heart, vascular protective receptor. In recent years, the research progress of AT in cardioprotection is reviewed.