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[目的]观察紫杉醇联合卡铂(TP)新辅助化疗Ⅱb期宫颈癌的临床效果。[方法]50例Ⅱb期宫颈癌患者,术前采用TP方案化疗1～2个疗程后行宫颈癌根治术。观察宫颈癌病灶、宫旁组织在化疗后的改变,化疗毒副反应以及术后病理反应情况等。[结果]化疗有效率为84%(42/50),且宫旁组织有不同程度的改善。新辅助化疗后42例(84%)患者进行广泛性子宫切除术及盆腔淋巴结清扫术。[结论]Ⅱb期宫颈癌术前TP方案化疗近期疗效显著,提高了手术的切除率。
[Objective] To observe the clinical effect of paclitaxel plus carboplatin (TP) neoadjuvant chemotherapy for stage Ⅱb cervical cancer. [Method] Fifty patients with stage Ⅱb cervical cancer underwent radical resection of cervical cancer after premedication with TP regimen for 1 ~ 2 cycles. Observation of cervical lesions, uterine tissue changes after chemotherapy, chemotherapy, side effects and postoperative pathological reactions. [Results] The effective rate of chemotherapy was 84% (42/50), and the paracancerous tissues had different degrees of improvement. Forty-two patients (84%) received extensive hysterectomy and pelvic lymphadenectomy after neoadjuvant chemotherapy. [Conclusion] The curative effect of TP chemotherapy before Ⅱb cervical cancer is significant, which improves the resection rate of the operation.