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目的:观察扶正泄浊保肾汤对5/6肾切除CRF大鼠动物模型的疗效,探讨该方药治疗CRF的部分机制。方法:采用5/6肾切除方法制造CRF模型。60只SD雄性大鼠随机分为六组:假手术组,模型组,对照组,中药大、中、小剂量组。大、中、小剂量组分别予扶正泄浊保肾汤,按29.4g/kg、19.6g/kg、9.8g/kg比例灌胃。假手术组及模型组予以生理盐水灌胃;对照组予以尿毒清颗粒灌肠。给药8周后处死大鼠,放射免疫法测定血清瘦素(Lepin)的含量。
Objective: To observe the curative effect of Fuzheng Xiezhuo Baoshen Decoction on 5/6 nephrectomy CRF rat model, and to explore the mechanism of this recipe in treating CRF. Methods: CRF model was made by 5/6 nephrectomy. Sixty SD male rats were randomly divided into six groups: sham operation group, model group, control group, Chinese medicine large, medium and small dose groups. Large, medium and low-dose groups were given to help clear Xiebaoxuesang soup, by 29.4g / kg, 19.6g / kg, gavage at a rate of 9.8g / kg. The rats in sham-operation group and model group were given normal saline intragastrically. The control group was given uremic-clear granule enema. The rats were sacrificed 8 weeks after the administration, and the content of Leptin was measured by radioimmunoassay.