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目的评价奥沙利铂联合紫彬醇方案治疗晚期胃癌的临床疗效和毒副反应。方法用奥沙利铂联合紫杉醇方案治疗胃癌患者20例。方案为:紫彬醇针:175mg/m。IV第1天,奥沙利铂针:100mg/m,IV第2天,3周为一疗程,每例完成4～6程。结果完全缓解(CR)1例,占5%。部分缓解(PR)5例,占25%。稳定(SD)7例,占35%。进展(PD)7例,占35%。临床受益率为65%,中位肿瘤进展时间5.5月,中位生存期11.5月。主要不良反应是白细胞及血小板减少以及胃肠道反应如恶心、呕吐,少见末梢神经病变,未出现治疗相关性死亡。结论奥沙利铂联合紫彬醇方案治疗晚期胃癌患者有效,临床缓解率高,明显减轻患者的痛苦,提高患者的生存质量,毒副作用患者能够耐受。因此,可作为胃癌的一线或二线治疗方案。
Objective To evaluate the clinical efficacy and side effects of oxaliplatin combined with purple bin alcohol in the treatment of advanced gastric cancer. Methods Twenty patients with gastric cancer were treated with oxaliplatin combined with paclitaxel. Program: Purple Bin alcohol needle: 175mg / m. IV Day 1, oxaliplatin needle: 100mg / m, IV Day 2, 3 weeks for a course of treatment, each completed 4 to 6 courses. The results of complete remission (CR) in 1 case, 5%. Partial relief (PR) in 5 cases, accounting for 25%. Stable (SD) in 7 cases, 35%. Progress (PD) in 7 cases, 35%. Clinical benefit rate was 65%, median tumor progression time 5.5 months, the median survival 11.5 months. The main adverse reactions were leukopenia and thrombocytopenia as well as gastrointestinal reactions such as nausea and vomiting, rare peripheral neuropathy, and no treatment-related deaths. Conclusion oxaliplatin combined with purple Bin alcohol regimen in patients with advanced gastric cancer effective, high remission rate, significantly reduce the patient’s pain and improve patient quality of life, patients with toxic side effects can be tolerated. Therefore, can be used as a first-line or second-line treatment of gastric cancer.