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目的探讨原发性肝癌(PHC)患者经无水酒精注射治疗后血清中肿瘤坏死因子(TNF)及甲胎蛋白(AFP)的变化及其与患者免疫功能变化的相关性。方法检测87例PHC患者无水酒精注射治疗后血清中TNF和AFP的改变,并与健康对照组20例比较,分析其与患者免疫功能变化的相关性。结果PHC患者治疗前血清TNF和AFP水平明显高于健康对照组(P<0.01);治疗后1周,血清TNF与治疗前比较无明显变化(P>0.05),而AFP下降明显(P<0.01);治疗后2周,血清TNF下降明显(P<0.01),但仍高于对照组(P<0.01),AFP降至正常,与对照组比较差异无显著性(P>0.05)。血清TNF与AFP水平变化无相关性(r=0.195,P>0.05)。无水酒精注射治疗PHC近期效果明显。结论原发性肝癌无水酒精注射治疗后血清中TNF及AFP水平下降,提示机体免疫功能增强,并有助于判断疗效及预后。
Objective To investigate the changes of serum tumor necrosis factor (TNF) and alpha-fetoprotein (AFP) in patients with primary hepatocellular carcinoma (PHC) treated with anhydrous alcohol injection and its correlation with the changes of immune function. Methods Serum levels of TNF and AFP were measured in 87 patients with PHC after alcohol injection. The changes of serum TNF and AFP levels were compared with those in healthy control group. The correlations were analyzed with the changes of immune function. Results The levels of serum TNF and AFP in patients with PHC before treatment were significantly higher than those in healthy controls (P <0.01). After 1 week of treatment, there was no significant difference in serum TNF before treatment (P> 0.05), but AFP decreased significantly (P <0.01) (P <0.01), but still higher than the control group (P <0.01). AFP decreased to normal level at 2 weeks after treatment. There was no significant difference between the two groups (P> 0.05). There was no correlation between serum TNF and AFP level (r = 0.195, P> 0.05). The effect of anhydrous alcohol injection PHC in the near future is obvious. Conclusion The decrease of serum TNF and AFP levels in patients with primary liver cancer treated with anhydrous alcohol injection suggests that the immune function of the patients is enhanced and the efficacy and prognosis of the patients with hepatocellular carcinoma can be evaluated.