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目的研究干扰素治疗慢性丙型肝炎近期疗效与远期疗效.方法3×106IU,im,1次/2d×3个月为1疗程,接受1~5个疗程干扰素治疗的慢性丙型肝炎患者68例,治疗结束后随访观察15年~3年.结果根据干扰素疗效的生物化学评判标准,第1个疗程治疗结束时,分别有765%(52/68),206%(14/68)和29%(2/68)的患者表现为完全应答、部分应答和不应答.519%(27/52)的完全应答者在第1个疗程结束后6个月~10个月的间歇内复发.分别有19,1和3例患者接受了共计2,3和5个疗程治疗.在1~5个疗程干扰素治疗结束之后15年~3年的随访观察中,29例(427%)患者表现为持续完全应答,其中4例患者HCVRNA检测结果持续阳性;37例(544%)患者为部分应答;2例(29%)患者无应答.结论慢性丙型肝炎患者干扰素治疗的早期疗效较好,但完全应答者的复发率较高.
Objective To study the short-term curative effect and long-term curative effect of interferon on chronic hepatitis C Methods A total of 68 patients with chronic hepatitis C were treated with 3 × 106IU, im, 1 time / 2d × 3 months for 1 course of treatment and 1 to 5 courses of interferon treatment. The patients were followed up for 15 years to 3 years after the end of treatment. Results According to biochemical criteria of efficacy of interferon, there were 76.5% (52/68), 20.6% (14/68) and 29% (2/68) cases, respectively, at the end of the first course of treatment. Of patients showed complete response, partial response and no response. 51.9% (27/52) of complete responders relapsed within the interval of 6 months to 10 months after the end of the first course of treatment. 19, 1 and 3 patients, respectively, received a total of 2, 3 and 5 courses of treatment. Of the 1 to 5 years to 3 years of follow-up after 1 to 5 courses of interferon treatment, 29 (42.7%) patients showed a sustained complete response, of which 4 cases continued to have positive HCV RNA test results and 37 (544%) patients were partial response; 2 patients (29%) patients had no response. Conclusion The early curative effect of interferon in patients with chronic hepatitis C is better, but the relapse rate of those with complete responders is higher.