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目的观察万汶预扩容对大容量肺灌洗(WHL)中低血压的防治效果。方法观察组(34例),于灌洗前30min内快速输注万汶500ml;对照组(56例)灌洗前不预防性快速补液。观察二组WHL中低血压的发生率及麻黄素的使用率。结果观察组低血压发生率为0.176(6/34),对照组低血压发生率为0.600(30/56),观察组低血压发生率明显低于对照组,二组比较差异有统计学意义,P<0.05。观察组麻黄素的使用率为0.059(2/34),对照组麻黄素的使用率为0.482(27/56),观察组麻黄素的使用率明显低于对照组,二组比较差异有统计学意义,P<0.05。结论大容量肺灌洗前预先静脉输注万汶500ml可有效减少WHL中低血压的发生。
Objective To observe the prevention and treatment effect of pre-dilation of Wan-wen on the hypotension in high-volume pulmonary lavage (WHL). Methods The observation group (n = 34) received rapid infusion of 500ml of Wenwen within 30 minutes before lavage and the control group (56 cases) received no prophylactic rapid rehydration before lavage. The incidence of hypotension in WHL and the usage of ephedrine in the two groups were observed. Results The incidence of hypotension was 0.176 (6/34) in the observation group and 0.600 (30/56) in the control group. The incidence of hypotension in the observation group was significantly lower than that in the control group. The difference between the two groups was statistically significant, P <0.05. The use rate of ephedrine in the observation group was 0.059 (2/34), while that in the control group was 0.482 (27/56). The utilization rate of ephedrine in the observation group was significantly lower than that of the control group Significance, P <0.05. Conclusions Pre-infusion of 500ml of Vancomycin before large-capacity lung lavage can effectively reduce the incidence of hypotension in WHL.