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Notch 信号通路参与机体多种细胞的凋亡调控，有证据表明在牙齿发育、牙齿损伤与修复、以及口腔肿瘤中均有 Notch 信号参与并可能与细胞凋亡调控相关。本文就 Notch 信号对细胞凋亡调控及其在口腔医学领域的研究进展作一综述。“,”Notch signaling pathway regulates apoptosis in multiple cell types.Recent evidences indicate that notch signaling is involved in tooth development,dental pulp injury and repair,oral cancer,and may play impor-tant role in regulation of cell apoptosis.Here we review the role of Notch signaling in cell apoptosis with emphasis on research progresses in stomatology.