目的了解组织细胞性坏死性淋巴结炎的临床病理特征。方法对１６例组织细胞性坏死性淋巴结炎患者进行回顾性分析。结果本病临床上以颈部淋巴结肿大、发热及外周血白细胞减少为主要表现；病理特征为淋巴结广泛凝固性坏死和组织细胞增生。糖皮质激素治疗有效。结论组织细胞性坏死性淋巴结炎是一个自限性淋巴结病变，在临床上及组织学上易与淋巴瘤相混淆，应引起临床医师注意 Objective To understand the clinicopathological features of histiocytic necrotizing lymphadenitis. Methods A retrospective analysis was performed on 16 patients with histiocytic necrotizing lymphadenitis. Results The clinical manifestations of cervical lymph nodes, fever and peripheral leukopenia as the main manifestations; pathological features of extensive coagulation necrosis and tissue cell proliferation. Glucocorticoid treatment is effective. Conclusions Histocystic necrotizing lymphadenitis is a self-limiting lymphadenopathy, which is confusing with lymphoma both clinically and histologically, and should be brought to the attention of clinicians