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目的比较促性腺激素释放激素激动剂（ＧｎＲＨａ）辅助超排卵和单纯促性腺激素（ＰＭＳＧ）超排卵对金黄地鼠子宫内膜的影响。方法模仿人类长周期，对金黄地鼠进行ＧｎＲＨａ预处理后，用ＰＭＳＧ超排卵（１０只，ＬＡ＋ＰＭＳＧ组），并以１０只单用ＰＭＳＧ超排卵（ＰＭＳＧ组）和１０只自然周期金黄地鼠（对照组）为对照，对子宫内膜进行组织学和超微结构分析。结果组织学检查显示：ＬＡ＋ＰＭＳＧ组子宫内膜成熟度与对照组相比，差异无显著性（Ｐ＞０．０５），而ＰＭＳＧ组子宫内膜明显发育延迟（Ｐ＜０．０１）。超微结构分析显示：ＬＡ＋ＰＭＳＧ组线粒体肿大，缺少线粒体脊，无网篮样结构；ＰＭＳＧ组线粒体明显减少。结论ＧｎＲＨａ辅助超排卵方案能促进生理性子宫内膜的形成，优于单独ＰＭＳＧ超排卵方案。但ＧｎＲＨａ辅助超排卵仍存在对子宫内膜超微结构的不良影响
Objective To compare the effect of gonadotropin-releasing hormone agonist (GnRH-a) -assisted superovulation and simple gonadotropin (PMSG) on ovary endometrium in golden hamster. Methods After simulating the long-term human cycle, GnRHa preconditioning was performed on golden hamsters. Ten pups of the golden hamster were treated with PMSG superovulation (10, LA + PMSG group) and 10 PMSG superovulation (PMSG group) Rats (control group) as a control, histological and ultrastructural analysis of the endometrium. Results The histological examination showed that there was no significant difference in the endometrial maturation between the LA + PMSG group and the control group (P> 0.05), while the PMSG group had a marked delayed development of the endometrium (P <0.01). Ultrastructural analysis showed that the mitochondria of LA + PMSG group were enlarged, lack of mitochondrial ridges, and no basket-like structure. Mitochondria of PMSG group were significantly reduced. Conclusions GnRH-a assisted superovulation can promote the formation of physiological endometrium, which is superior to the PMSG superovulation alone. However, GnRH-a-assisted superovulation still has adverse effects on the ultrastructure of the endometrium