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流感病毒是目前危害人类健康的主要病原微生物之一,不但造成了巨大的经济损失,而且影响着社会的稳定。除了偶尔出现的流感大暴发,每年都有不少人死于季节性流感。尤其是2013年在中国暴发的H7N9禽流感疫情,目前感染人数已超过600例,死亡人数超过200人,病毒已经在中国定居,每年冬春季都会出现病例。流感病毒的天然宿主是禽类,而禽流感病毒如何突破种间屏障去感染人,是病毒学家一直关心的重要科学问题。主要描述了病毒受体结合特性影响跨种传播的分子机制,包括H1、H2、H3、H5、H6、H7、H9、H10等不同亚型流感病毒受体结合特性转变的结构基础,为流感病毒防控提供重要的理论基础。
Influenza virus is currently one of the major pathogenic microorganisms that endanger human health, not only caused huge economic losses, but also affected the social stability. In addition to the occasional flu outbreak, many people die of seasonal flu each year. In particular, the outbreak of H7N9 outbreak in China in 2013 has now exceeded 600 cases and the number of deaths exceeded 200. The virus has settled in China and cases occur in winter and spring each year. The natural host of influenza virus is poultry, and how the bird flu virus breaches the interspecies barrier to infect humans is an important scientific issue that virologists have long been concerned about. Mainly describes the molecular mechanism of virus receptor binding characteristics affecting transnational spread, including the structural basis of the transformation of the binding characteristics of influenza virus receptors of different subtypes H1, H2, H3, H5, H6, H7, H9 and H10, Prevention provides an important theoretical basis.