本文对10例足月妊娠肝内胆汁淤积症胎盘和10例同期足月胎盘进行了光镜和电镜对比观察.提示妊娠期肝内胆汁淤积症胎盘终末绒毛细胞滋养细胞增生、绒毛血管合体膜减少、合体芽增加.电镜下合体细胞微绒毛肿胀、稀少、粗面内质网普遍扩张,部分合体细胞线立体肿胀、溶酶体增加、胎儿毛细血管内皮细胞肿胀等改变 In this paper, 10 cases of full-term pregnancy intrahepatic cholestasis of the placenta and 10 cases of full-term placenta were observed by light microscopy and electron microscopy, suggesting that intrahepatic cholestasis of pregnancy placental terminal villi trophoblast hyperplasia, villus vascular syncytial membrane Reduced, the buds of syncytiotrophoblast increased.Under electron microscope, the microvilli of swollen cells were swollen, sparse, the general expansion of rough endoplasmic reticulum, the swelling of some syncytial cells, the increase of lysosomes and the swelling of fetal capillary endothelial cells