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目的研究食管癌组织中肿瘤转移相关基因1(MTA1)蛋白的表达及其与患者临床病理特征和预后的关系。方法选取黄石市中心医院病理科2010年1月至2013年1月收集的术后病理确诊的食管癌组织标本69例(食管癌组)及距离食管癌组织5 cm以上的正常食管组织标本30例(正常组)进行免疫组化染色观察,比较两组标本中MTA1蛋白阳性表达率的差异,分析MTA1蛋白阳性表达率与食管癌患者临床病理特征和预后的关系。结果食管癌组织中的MTA1蛋白阳性表达率72.46%显著高于癌旁组织中的0(χ~2=51.652,P<0.01);食管癌组织中的MTA1蛋白阳性表达与患者的TNM分期、浸润程度、淋巴结转移具有显著的关系(P<0.05,P<0.01);经过36个月的随访观察,MTA1蛋白阳性表达食管癌患者的3年存活率为32.00%(16/50),显著低于MTA1蛋白阴性表达患者的63.16%(12/19)(χ~2=5.543,P<0.05);MTA1蛋白阳性表达食管癌患者的3年中位生存时间29.0个月,显著低于MTA1蛋白阴性表达食管癌患者的33.0个月。结论 MTA1蛋白在食管癌组织中呈高表达,并且与患者的不良预后具有一定的关系。
Objective To study the expression of metastasis-associated gene 1 (MTA1) in esophageal carcinoma and its relationship with clinicopathological features and prognosis. Methods Sixty-nine cases of esophageal cancer tissues (esophageal cancer group) and 30 cases of esophageal cancer tissues above 5 cm from January 2010 to January 2013 were collected. (Normal group) were immunohistochemically stained. The difference of MTA1 protein positive expression rate was compared between the two groups. The relationship between the expression of MTA1 protein and the clinicopathological features and prognosis of esophageal cancer patients was analyzed. Results The positive rate of MTA1 protein in esophageal cancer tissues was 72.46%, which was significantly higher than that in adjacent tissues (χ ~ 2 = 51.652, P <0.01). The positive expression of MTA1 protein in esophageal cancer tissues was significantly correlated with TNM stage, (P <0.05, P <0.01). After 36 months of follow-up, the 3-year survival rate of MTA1 positive esophageal cancer patients was 32.00% (16/50), which was significantly lower than that of MTA1 protein positive esophageal cancer patients 63.16% (12/19) patients with MTA1 negative expression (χ ~ 2 = 5.543, P <0.05). The 3-year median survival time of MTA1 positive esophageal cancer patients was 29.0 months, which was significantly lower than that of MTA1 negative expression Esophageal cancer patients 33.0 months. Conclusion MTA1 protein is overexpressed in esophageal cancer tissues and has a certain relationship with poor prognosis.