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十全大补汤由黄芪、当归、茯苓等十味中药组成,能够减轻抗癌药副作用,增强机体抗肿瘤活性,增强补体C3活性和巨噬细胞活性,并刺激机体对绵羊红细胞的免疫反应,增强T淋巴细胞免疫并增强迟发性超敏反应。然而对十全大补汤中多糖成分的免疫活性及作用机理报道尚少。本次研究了当归、茯苓多糖的免疫调节作用。 材料与方法:①当归多糖与茯苓多糖的制备:干燥生药1kg经甲醇回流提取后的残渣用蒸馏水10L回流提取2h,浓缩
Shiquan Dabu Tang is made up of 10 Chinese herbal medicines, including Astragalus membranaceus, Angelica sinensis, Radix Astragali and so on. It can reduce the side effects of anticancer drugs, enhance the body’s anti-tumor activity, enhance complement C3 activity and macrophage activity, and stimulate the body’s immune response to sheep red blood cells. Enhance T-lymphocyte immunity and enhance delayed-type hypersensitivity. However, there are few reports on the immune activity and mechanism of polysaccharides in Shiquandabutang. The immunomodulatory effects of Angelica sinensis and Lycium barbarum polysaccharides were studied in this study. MATERIALS AND METHODS: 1 Preparation of Angelica polysaccharides and Lycium barbarum polysaccharides: Residues of dried crude drug 1 kg extracted with methanol were extracted with 10 L of distilled water and refluxed for 2 h.