对饮食与胆固醇结石(CS)的关系国内外已有较多的研究。关于胆色素结石(PS)的成因,以往认为与胆道感染、胆汁郁积等因素有关;但近年来的一些研究表明,饮食中某些成分(尤其是蛋白质和脂肪)对 PS 的形成亦具有十分重要的影响,本文拟对此进行初步的讨论。流行病学研究四十年代,日本人的胆石症中60～80%为 PS。近年来,日本的 PS 发病率已明显减少,而 CS 则显著增多,并且逐渐成为主要的胆石类型,Matsushiro 报告占85%以上。这一趋势可归因于日本人生活方式的改变,特别是与饮食成分的改变有关。1949年,日 The relationship between diet and cholesterol stones (CS) has been more research at home and abroad. On the causes of biliary pigment stones (PS), in the past that with the biliary tract infection, cholestasis and other factors; but in recent years, some studies have shown that some of the dietary ingredients (especially protein and fat) on the formation of PS is also very important This article intends to conduct a preliminary discussion of this. Epidemiological studies In the 1940s, 60-80% of Japanese cholelithiasis was PS. In recent years, the incidence of PS in Japan has been significantly reduced, while that of CS has increased significantly, becoming a major type of gallstone. Matsushiro reports more than 85%. This trend can be attributed to changes in the way of life of the Japanese, especially with changes in diet composition. 1949, day