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目的:研究体外受精胚胎移植(IVF-ET)中注射绒毛膜促性腺素(HCG)前后雌二醇(E2)变化对IVF-ET结局预测价值。方法:放射免疫法检测193例行IVF-ET助孕患者注射HCG前后外周血E2水平,根据注射HCG后E2变化分为增高组(GroupⅠ)和降低组(GroupⅡ),降低组又根据E2降低百分比分为A、B、C、D4组,比较各组的种植率和临床妊娠率。结果:GroupⅠ和GroupⅡ两组种植率和临床妊娠率差异无统计学意义,分别为28.9%VS22.1%和45.0%VS38.2%(P>0.05)。A、B、C、D各组的种植率分别为29.7%、22.4%、18.7%、19.4%(P>0.05),临床妊娠率分别为45.5%、39.0%、32.8%、42.9%,经比较差异无显著性(P>0.05)。结论:HCG注射后E2水平变化不能预测IVF-ET结局。
Objective: To investigate the predictive value of estradiol (E2) before and after injection of human chorionic gonadotropin (HCG) on IVF-ET outcome in IVF-ET. Methods: Radioimmunoassay was used to detect E2 levels of peripheral blood before and after HCG injection in 193 patients with IVF-ET-assisted pregnancy. According to E2 changes after HCG injection, the patients were divided into two groups: Group Ⅰ and Group Ⅱ, Divided into A, B, C, D4 group, compare the planting rate and clinical pregnancy rate of each group. Results: There was no significant difference in implantation rate and clinical pregnancy rate between Group Ⅰ and Group Ⅱ, which were 28.9% VS22.1% and 45.0% VS38.2%, respectively (P> 0.05). The implantation rates of groups A, B, C and D were 29.7%, 22.4%, 18.7% and 19.4% respectively (P> 0.05). The clinical pregnancy rates were 45.5%, 39.0%, 32.8% and 42.9% There was no significant difference (P> 0.05). Conclusion: The change of E2 level after HCG injection can not predict the outcome of IVF-ET.