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目的癌性胸膜腔积液是晚期癌症的严重并发症之一,单纯留置导管放液效果不佳,笔者所在医院于2001～2004年共收治癌性胸膜腔积液患者60例,其中32例于放液后胸膜腔内注入多抗甲素,取得良好疗效。方法 60例患者随机分为两组:A组32例,B组28例,均行全身化疗并胸膜腔内留胃中央静脉导管,A组患者每7天注入一次多抗甲素20 mg+生理盐水20 ml,注入药物后闭管24 h,嘱患者转动体位,以利药物混匀。B组患者仅行胸膜腔内置管引流。结果试验组(A组)有效例数与对照组(B组)有效例数比较,经χ~2检验有显著差异(P<0.05)。结论本组使用胸膜腔内注入多抗甲素治疗癌性心包积液,症状改善,患者存活时间延长。
The purpose of cancerous pleural effusion is one of the serious complications of advanced cancer, indwelling catheter indwelling poor results, the author hospital from 2001 to 2004, a total of 60 patients with cancerous pleural effusion, including 32 cases of After pleural effusion injection of poly-A, achieved good results. Methods Sixty patients were randomly divided into two groups: group A (32 cases) and group B (group B) with systemic chemotherapy and intrapleural central venous catheterization. Patients in group A were injected with poly-A 20 mg + saline every 7 days 20 ml, closed the tube after injection of drugs 24 h, Zhu Huanzhe rotation position, to facilitate drug mixing. Patients in group B underwent drainage only in the pleural cavity. Results The number of effective cases in the test group (A group) was significantly different from that in the control group (B group) (P <0.05). Conclusion This group used pleural cavity injection of poly-A for the treatment of malignant pericardial effusion, the symptoms improved, and the patient’s survival time was extended.