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目的比较经腹腔化疗及外周静脉化疗对晚期胃肠道恶性肿瘤患者生存质量的影响。方法对无法切除的晚期消化道肿瘤采用经腹腔化疗(60例)、外周静脉化疗(32例)两种不同的化疗方式,分别于术前和术后2、5、10、20、30周测定胃肠道生活质量(GQLI)指数。结果术前、术后2、5周两组GQLI指数差异不明显,术后10、20、30周两组GQLI指数差异有显著性意义,P<0.01;静脉化疗组患者GQLI指数明显下降。腹腔化疗组的1年生存率高于外周静脉化疗组,P<0.05。结论经腹腔化疗较外周静脉化疗能提高晚期消化道肿瘤患者的生存质量。
Objective To compare the effect of intraperitoneal chemotherapy and peripheral intravenous chemotherapy on the quality of life of patients with advanced gastrointestinal cancer. Methods Two different chemotherapy methods were used for the unresectable advanced gastrointestinal cancers: intraperitoneal chemotherapy (60 cases) and peripheral vein chemotherapy (32 cases), which were measured before and at 2, 5, 10, 20, and 30 weeks after operation. Gastrointestinal quality of life (GQLI) index. Results There was no significant difference in GQLI index between preoperative and postoperative 2 and 5 weeks. There was significant difference in GQLI index between the two groups at 10, 20, and 30 weeks postoperatively (P<0.01). The GQLI index was significantly decreased in the intravenous chemotherapy group. The 1-year survival rate in the intraperitoneal chemotherapy group was higher than that in the peripheral intravenous chemotherapy group, P<0.05. Conclusion Compared with peripheral vein chemotherapy, intraperitoneal chemotherapy can improve the quality of life of patients with advanced gastrointestinal cancer.