本大综述近十余年来关于缺血心肌跨膜电位变化原理研究的主要成果;指出阻断冠脉血流早期阶段细胞内外生化环境的各种变化;着重讨论缺氧、高血钾、高乳酸、酸中毒和脂类代谢异常等因素对心肌跨膜电位的影响以及上述各因素在缺血心肌跨膜电位变化中所起的主要作用。 This review summarizes the main results of the study on the principle of transmembrane potential changes in ischemic myocardium over the past decade or so; points out various changes that block the biochemical and physiological conditions inside and outside cells in the early stages of coronary blood flow; and focuses on hypoxia, hyperkalemia, Lactic acid, acidosis and lipid metabolism and other factors on myocardial transmembrane potential and the above factors in the ischemic myocardial transmembrane potential changes play a major role.