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ｐ5 3基因是至今发现与人类恶性肿瘤相关性最高的基因 ,约 5 0 %的人类恶性肿瘤中存在 ｐ5 3基因的异常[1] 。近年还发现 ｐ5 3功能异常与肿瘤对化疗、放疗的不敏感有关[2 ,3 ] 。因此在基因治疗的研究中ｐ5 3基因的地位十分突出。卵巢肿瘤是妇科常见的恶性肿瘤 ,难于早期诊断
The p5 3 gene is the one with the highest correlation with human malignant tumors so far, and about 50% of human malignancies have the abnormalities of p5 3 gene [1]. In recent years, it has also been found that p5 3 dysfunction is related to the tumor’s insensitivity to chemotherapy and radiotherapy [2,3]. Therefore, in the gene therapy research p5 3 gene status is very prominent. Ovarian cancer is a common gynecological cancer, difficult to diagnose early