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目的 研究血必净联合血液净化治疗急性胰腺炎的效果及对炎症因子的影响.方法 选取2015年9月—2017年7月在苏州市立医院就诊的确诊为重症急性胰腺炎患者62 例, 按照治疗方案不同,采用随机分组,分为观察组与对照组各31 例,其中对照组予常规治疗,观察组在常规治疗基础上予血必净联合血液净化治疗.统计对比两组腹痛缓解时间、住院时间、死亡率、MODS、治疗前后血清炎症因子hs-CRP、TNF-α、IL-6、IL-8水平.结果 治疗前,两组血清hs-CRP、TNF-α、IL-6、IL-8水平差异无统计学意义(P＞0.05),治疗后两组血清hs-CRP、TNF-α、IL-6、IL-8水平均较治疗前显著下降,差异具有统计学意义(P＜0.05),治疗后观察组血清hs-CRP、TNF-α、IL-6、IL-8水平低于对照组,住院时间、腹痛缓解时间均低于对照组,差异具有统计学意义(P＜0.05).结论 血必净联合血液净化治疗急性胰腺炎临床治疗效果显著,减少住院时间,减轻患者疼痛程度,更好地抑制炎症反应,显著减少了并发症的发生.“,”Objective To study the effect of Xuebijing combined with blood purification in the treatment of acute pancreatitis and its influence on inflammatory factors. Methods A total of 62 patients diagnosed with severe acute pancreatitis were selected from September 2015 to July 2017 in Suzhou Municipal Hospital. According to the different treatment options, the patients were randomly divided into the observation group (n＝31) and the control group (n＝31). The control group received conventional treatment, while the observation group received Xuebijing combined with blood purification treatment on the basis of conventional treatment. The abdominal pain relief time, hospital stay, mortality, MODS, serum inflammatory factors hs-CRP, TNF-α, IL-6 and IL-8 levels before and after treatment were compared between the two groups. Results Before the treatment, there was no statistically significant difference in serum hs-CRP, TNF-α, IL-6 and IL-8 levels between the two groups (P＞0.05). After the treatment, the serum hs-CRP, TNF-α, IL-6 and IL-8 levels decreased significantly in the two groups (P＜0.05). The levels of serum hs-CRP, TNF-α, IL-6 and IL-8 in the observation group were lower than those in the control group, and the time of abdominal pain relief and hospital stay were lower than those in the control group. The difference was statistically significant (P＜0.05). Conclusion Xuebijing combined with blood purification for the treatment of acute pancreatitis has a significant clinical effect, reducing the length of hospital stay, alleviating the pain degree of patients, inhibiting inflammatory reactions and significantly decreasing the incidence of complications.