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目地探讨口服降糖药物(OADs)失效的2型糖尿病(T2DM)患者初次胰岛素治疗方案。方法符合标准的2型糖尿病患者28例,给予诺和灵30R联合二甲双胍治疗30周,比较治疗前后的空腹血糖(FPG)、餐后两小时血糖(2HPG)及糖化血红蛋白(HbA1c)的结果。统计学方法采用t检验。结果HbA1c良好达到率46%(13/28),理想达到率为32%(9/28),总达到率为78%(22/28)。治疗后FGP、2HPG和HbA1c与治疗前比较明显下降,有显著性差异(P<0.01)。结论作为OADs失效的2型糖尿病患者的初始胰岛素治疗方案,预混胰岛素联合二甲双胍治疗可以显著改善血糖控制水平,同时不增加低血糖发生危险和避免体重增加。
Objective To investigate the initial insulin treatment of type 2 diabetes mellitus (T2DM) patients with oral hypoglycemic drugs (OADs) failure. Methods Forty-eight patients with type 2 diabetes were treated with Novolin 30R and metformin for 30 weeks. The results of fasting blood glucose (FPG), two-hour postprandial blood glucose (2HPG) and HbA1c were compared before and after treatment. Statistical methods using t test. Results HbA1c achieved a good rate of 46% (13/28), an ideal rate of 32% (9/28) and a total rate of 78% (22/28). After treatment, FGP, 2HPG and HbA1c significantly decreased compared with those before treatment, with significant difference (P <0.01). Conclusions As an initial insulin regimen for type 2 diabetes patients with OADs failure, premixed insulin plus metformin treatment significantly improves glycemic control without increasing the risk of hypoglycaemia and avoiding weight gain.