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目的采用共词分析法对近5年来国内外儿童超说明书用药的研究现状进行可视化分析,展现该领域的研究情况,描绘儿童超说明书用药的研究趋势,为未来的研究提示可能的方向。方法于2014年8月分别以主题词“儿童”及“超说明书用药”在CNKI数据库、以主题词“pediatric”及“off-label drug”在MEDLINE数据库进行文献检索及筛选,提取文献高频关键词并使用Excel 2013建立共现矩阵,使用Ucinet 6.2绘制可视化网络。结果初步建立国内外儿科超说明书用药研究现状的可视化网络,反映了近年来该研究领域的热点及现状。结论国内外儿童超说明书用药的现象都较常见。我国对儿童超说明书用药的关注始于近3年;而国外对于儿童超说明书的关注时间较长,研究范围覆盖广,且已有针对超说明书用药的临床试验。现阶段国内外都急需要对儿童超说明书用药进行规范化管理,及时进行相关临床试验以更新说明书关于儿童用药的部分,保证儿童患者的用药安全。
Objective To analyze the current situation of research on the use of hyper-description of children in the past five years by using the method of co-word analysis, to show the research situation in this field and to depict the research trend of children’s super-instruction drug, so as to suggest possible directions for future research. Methods The MEDLINE database was searched in the CNKI database with the keywords of “children” and “super instructions drug” in August 2014 with the keywords of “pediatric” and “off-label drug” And filtering, extracting high frequency keywords from the literature and building a co-occurrence matrix using Excel 2013, and visualizing the network using Ucinet 6.2. Results The preliminary establishment of a visualization network for the current research on the pediatric super instruction manuals at home and abroad reflects the hotspot and current situation of the research field in recent years. Conclusion Children and children at home and abroad over the phenomenon of drug use are more common. Concerns over the use of drugs in children in China began in recent three years. However, foreign countries have paid more attention to children’s manuals, covering a wide range of research areas and have already conducted clinical trials on drugs. At this stage both at home and abroad are in urgent need of standardized management of children’s super manual medication, timely relevant clinical trials to update the manual on the part of children’s medication, to ensure the safety of children’s medication.