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目的 :介绍受体克隆技术与转基因动物在药物筛选中的应用。方法 :对近年来重组受体、转基因动物、基因探针等基因工程技术在药物筛选中的应用加以归纳、综述。结果 :受体克隆技术与转基因动物与药物筛选相结合为人类发现了许多有新颖药理作用的先导化合物。结论 :受克隆技术与转基因动物是新药筛选方法上的革命。
Objective: To introduce the application of receptor cloning technology and transgenic animals in drug screening. Methods: In recent years, recombinant receptors, transgenic animals, genetic probes and other genetic engineering techniques in drug screening are summarized, reviewed. Results: The combination of receptor cloning technology and transgenic animals and drug screening found many novel lead compounds with novel pharmacological actions. Conclusion: Cloned technology and transgenic animals are revolutions in the screening of new drugs.