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脑梗塞的发病涉及血管壁、血流动力学及血流状态等多种因素、过去对血流状态进行了许多研究.包括对病人凝血、抗凝双纤港的测定,对这些功能的测定有助于评价病人的病理生理状态和指导临床治疗.尤其是溶栓疗法用于治疗脑梗塞后,全面准确评价纤溶系统的功能显得更为重要,最近建立了测定交联纤维蛋白特异性降解产物D一二聚体(D-dimer,DD)的方法、认为DD可更准确地用于体内纤溶系统的功能状态.本研究使用单克隆抗体酶联免疫吸附试验(ELISA)测定了脑梗塞病人血中DD含量,以评价脑梗塞急性期DD的变化及其临床意义.1 材料和方法1.1 研究对象 随机选择我院神经内科收治发病1周内的急性脑梗塞病人48例(病人组),除外已使用溶栓治疗者、均经头颅CT和(或)MR1确证,根据影像学把病人分为皮层支梗塞组(CAO)和深穿支梗塞组(PAO).每个病人均按统一的量表进行神经系统功能缺损评分.
The incidence of cerebral infarction involves the vascular wall, hemodynamics and blood flow status and many other factors, the blood flow in the past conducted a lot of research, including the determination of patients with coagulation, anticoagulation Shuangxian Hong, the determination of these functions are Help to assess the patient’s pathophysiology and guide the clinical treatment.Especially thrombolytic therapy for the treatment of cerebral infarction, a comprehensive and accurate evaluation of the function of the fibrinolytic system is even more important, the establishment of a recently established cross-linked fibrin-specific degradation products D-dimer (DD) method, that DD can be more accurately used for the functional status of the fibrinolytic system in vivo.In this study, the use of monoclonal antibody enzyme-linked immunosorbent assay (ELISA) determination of cerebral infarction patients DD content in the blood to assess the changes in the acute phase of cerebral infarction DD and its clinical significance.1 Materials and Methods 1.1 Subjects randomly selected in our hospital neurology admitted to the onset of acute cerebral infarction within 1 week in 48 patients (patient group), except Patients who had been treated with thrombolysis were classified by cranial computed tomography and / or MR1 according to radiographic criteria, and were divided into a cortical branch infarction (CAO) group and a deep penetration branch infarction (PAO) group, Table for nerve System impairment score.