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铅是一种广泛分布的元素,人们日常生活接触铅的机会越来越多。已知有机铅的毒性大于无机铅,且主要作用于神经组织,但其作用机制尚不清楚,因此作者研究了三乙基铅(TEL)对中枢神经系统的脂质过氧化作用及与大脑各区域神经递质受体结合的能力。实验一:雌性8～10周龄Fischer 344大鼠40只,随机分成四组。三组为实验组给予TEL1.75mg/kg;一组为对照组给予等量的燕馏水,每日腹腔注射一次,共5天。分别于停药后1、7、21天处死动物,用硫代巴比妥酸比色法测定大脑皮质区、海马及小脑的脂质过
Lead is a widely distributed element and people are exposed to lead in their daily lives more and more. It is known that organic lead is more toxic than inorganic lead and mainly acts on nerve tissue. However, its mechanism of action is unclear. Therefore, the author has studied the effects of triethyl lead (TEL) on lipid peroxidation of the central nervous system, Regional neurotransmitter receptor binding ability. Experiment 1: 40 female Fischer 344 rats aged 8-10 weeks were randomly divided into four groups. Three groups for the experimental group was given TEL1.75mg / kg; one group for the control group was given the same amount of distilled water, intraperitoneal injection once a day for 5 days. Animals were sacrificed on days 1, 7 and 21, respectively, after discontinuation, and lipid peroxidation in cerebral cortex, hippocampus and cerebellum was measured by thiobarbituric acid colorimetry