为了观察血小板激活因子(PAF)在急性低压缺氧中的作用,选用了天然PAF拮抗剂Taponin进行缺氧干预实验.结果发现,用0.5g/kg剂量给大鼠灌胃给药8次,对急性低压缺氧引起的大鼠心肌、肝功能和内皮细胞损害有较好保护作用,血液中的CPK、LDH、α-HBD、AST、ALT、γ- GT以及 ET含量均未见明显升高,和对照组相比,差异无显著性(P>0.05).另外,本实验还发现,20%的低浓度乙醇对急性低压缺氧也有一定的保护作用. In order to observe the role of platelet activating factor (PAF) in acute hypobaric hypoxia, a natural PAF antagonist, Taponin, was used in the experiment of hypoxia, and the results showed that 0.5g / kg dose was given to rats intragastrically for 8 times, Acute hypobaric hypoxia induced myocardial, liver function and endothelial cell damage in rats with good protective effect, blood levels of CPK, LDH, α-HBD, AST, ALT, γ-GT and ET were not significantly increased, Compared with the control group, the difference was not significant (P> 0.05) .In addition, this experiment also found that 20% low concentration of ethanol on acute hypobaric hypoxia also have some protective effect.