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笔者报告服用甲硝唑(metronidazole,又名灭滴灵)后产生神经精神障碍2例。例1 男,20yr,精神分裂症。经用氯丙嗪600 mg/d治疗,精神症状已消失。因牙周炎服甲硝唑600mg/d,分次给药、12d后出现全身震颤,共济失调,四肢过度屈曲,意识不清并伴有幻听、幻视,内容为恐怖性小动物,表情紧张、焦虑,事后不能回忆。因不能肯定何药引起,在医护人员严密注视下,停服氯丙嗪,保留甲硝唑,观察1wk,神经精神症状仍然存在;停服甲硝唑,重新予氯丙嗪600mg/d,3d内所有神经精神症状和体征均消失,意识
I report the use of metronidazole (metronidazole, also known as metronidazole) in 2 cases of neuropsychiatric disorders. Example 1 male, 20yr, schizophrenia. After treatment with chlorpromazine 600 mg / d, the psychiatric symptoms have disappeared. Due to periodontitis metronidazole 600mg / d, divided doses, 12 days after the occurrence of general tremor, ataxia, limbs over flexion, confusion and accompanied by auditory hallucinations, visual hallucinations, the contents of the terrorist animals, Tense, anxious, can not remember afterwards. Because of the drug can not be sure, under the close attention of medical staff, stop taking chlorpromazine, keep metronidazole, observation 1wk, neuropsychiatric symptoms still exist; stop taking metronidazole, re-given chlorpromazine 600mg / d, 3d All neuropsychiatric symptoms and signs disappeared, awareness