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目的探讨皮肤交感反应在糖尿病周围神经病变(DNP)早期诊断中的价值。方法 120例无明显症状的DNP患者作为观察组,另选取同期120例健康体检者作为对照组。检测两组交感神经皮肤反应(SSR)及神经传导速度(NCV),比较两组SSR及NCV异常情况、SSR各参数变化,统计观察组上下肢SSR及NCV异常情况。结果观察组SSR异常率为71.67%、NCV异常率为48.33%,明显高于对照组的11.67%、5.00%,差异有统计学意义(P<0.05)。观察组下肢SSR异常率为43.33%、NCV异常率为31.67%,明显高于上肢的28.33%、16.67%,差异有统计学意义(P<0.05)。观察组上肢潜伏期、下肢潜伏期、上肢波幅、下肢波幅与对照组比较差异有统计学意义(P<0.05)。结论 SSR是DNP早期的有效诊断指标,能够更早发现周围神经损害,是一种可靠的临床诊断方法。
Objective To investigate the value of skin sympathetic reaction in the early diagnosis of diabetic peripheral neuropathy (DNP). Methods One hundred and twenty DNP patients with no obvious symptoms were selected as the observation group. Another 120 healthy subjects were selected as the control group. The sympathetic skin reaction (SSR) and nerve conduction velocity (NCV) were measured in two groups. The abnormalities of SSR and NCV in both groups were observed. The changes of SSR parameters were observed. The abnormalities of SSR and NCV were observed. Results The abnormal rate of SSR in observation group was 71.67%, the abnormal rate of NCV was 48.33%, which was significantly higher than that in control group (11.67%, 5.00%, P <0.05). The abnormal rate of SSR in the lower extremity in observation group was 43.33%, the abnormal rate of NCV was 31.67%, which was significantly higher than that of upper extremity (28.33%, 16.67%, P <0.05). The latency of upper limbs, latency of lower extremity, upper extremity amplitude and lower extremity amplitude in observation group were significantly different from those in control group (P <0.05). Conclusion SSR is an effective early diagnosis of DNP, which can detect peripheral nerve damage earlier and is a reliable clinical diagnosis method.