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目的观察不同剂量左氧氟沙星治疗下呼吸道感染的有效性及安全性,为临床提供参考。方法回顾性分析医院收治的下呼吸道感染患者120例临床资料,随机分为试验组和对照组,每组60例。对照组采用小剂量左氧氟沙星进行治疗,试验组采用大剂量左氧氟沙星进行治疗,观察2组患者治疗后总有效率、症状缓解时间、不良反应发生率及生活质量评分。结果试验组总有效率为95.00%,高于对照组的81.67%(P<0.05);但2组不良反应发生率比较差异无统计学意义(P>0.05)。试验组症状缓解时间、生活质量评分均显著优于对照组(P<0.01)。结论针对下呼吸道感染患者采用大剂量左氧氟沙星治疗的临床疗效显著,安全性高,可促进患者早日康复,值得临床推广应用。
Objective To observe the effectiveness and safety of different doses of levofloxacin in the treatment of lower respiratory tract infection and provide reference for clinical practice. Methods The clinical data of 120 patients with lower respiratory tract infection admitted to the hospital were retrospectively analyzed. They were randomly divided into experimental group and control group, 60 cases in each group. The control group was treated with low-dose levofloxacin. The experimental group was treated with high-dose levofloxacin. The total effective rate, symptom relief time, incidence of adverse reactions and quality of life were observed in two groups after treatment. Results The total effective rate was 95.00% in the experimental group, which was 81.67% higher than that in the control group (P <0.05). However, there was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). The symptom relief time and quality of life in the experimental group were significantly better than those in the control group (P <0.01). Conclusion The clinical efficacy of high-dose levofloxacin for patients with lower respiratory tract infection is significant, safe and can promote the early recovery of patients, which is worthy of clinical application.