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目的探讨免疫球蛋白和T淋巴细胞在α地中海贫血患儿中的临床诊断意义。方法对来我院诊治的80例患者入院资料进行分析,将其随机分为两组。对照组为健康者,实验组为α地中海贫血患儿,采用免疫比浊法测定两组的免疫球蛋白M、A、G水平,并采用流式细胞仪检测对患者T淋巴细胞群进行检测。结果两组免疫球蛋白Ig A、Ig G、Ig M水平无统计学意义(P>0.05);T淋巴细胞中,实验组CD3+水平为(47.6±4.13)%、CD4+为(34.1±3.18)%、CD4/CD8为(1.02±1.56),低于对照组(P<0.05),两组CD8+差异不显著(P>0.05);三组地贫患者免疫球蛋白Ig A、Ig G、Ig M水平无统计学意义(P>0.05);中间型患儿T淋巴细胞CD3+、CD4+、CD4/CD8低于其他两组(P<0.05),三组CD8+水平差异不显著(P>0.05);且静止型与轻型之间差异不显著(P>0.05)。结论α地中海贫血发病率较高,临床上测定免疫球蛋白和T淋巴细胞的水平可对该病的诊疗及预后有一定的作用。
Objective To investigate the clinical significance of immunoglobulin and T lymphocyte in children with alpha thalassemia. Methods 80 hospitalized patients who came to our hospital were analyzed for admission data and randomly divided into two groups. The control group was healthy, and the experimental group was children with α-thalassemia. Immunoglobulin M, A and G levels were measured by immunoturbidimetric assay. T lymphocyte population was detected by flow cytometry. Results The levels of IgA, Ig G and Ig M in two groups had no statistical significance (P> 0.05). In T lymphocytes, the level of CD3 + in the experimental group was (47.6 ± 4.13)% and the percentage of CD4 + was 34.1 ± 3.18 , CD4 / CD8 (1.02 ± 1.56), lower than the control group (P <0.05), no significant difference between the two groups of CD8 + (P> 0.05); three groups of thalassemia patients immunoglobulin Ig A, Ig G, Ig M levels (P> 0.05). The levels of CD3 +, CD4 +, CD4 / CD8 of T lymphocytes in intermediate children were lower than those in the other two groups (P <0.05), while there was no significant difference between the three groups (P> 0.05) No significant difference between type and light (P> 0.05). Conclusion The prevalence of α-thalassemia is high. The clinical determination of immunoglobulin and T-lymphocyte levels may play a role in the diagnosis and prognosis of the disease.