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目的探讨紫杉醇联合卡铂作为新辅助化疗方案对局部晚期宫颈癌的疗效。方法 2012年2月-2013年2月间我院34例局部晚期宫颈癌患者行紫杉醇联合卡铂新辅助化疗,1-2个疗程后观察疗效。结果①所有患者肿瘤体积均有不同程度的缩小,宫颈软组织变软、间隙增宽,阴道充血减轻。②完全缓解4例(11.76%),部分缓解23例(67.65%),疾病稳定7例(20.59%)。③31例患者在化疗结束后均行广泛子宫切除术、盆腔淋巴结清扫术、双侧附件切除术,3例患者在化疗结束后均行广泛子宫切除术、盆腔淋巴结清扫术、卵巢悬吊术,手术率为100%。④所有患者化疗期间均出现一定程度的化疗副反应,主要有骨髓抑制、消化道反应、脱发等,按WHO分度标准上述化疗副反应均≤Ⅰ级。结论紫杉醇联合卡铂治疗局部晚期宫颈癌疗效确切、安全性好。
Objective To investigate the efficacy of paclitaxel combined with carboplatin as a neoadjuvant chemotherapy for locally advanced cervical cancer. Methods From February 2012 to February 2013, 34 patients with locally advanced cervical cancer in our hospital underwent neoadjuvant chemotherapy with paclitaxel and carboplatin. The curative effect was observed after 1-2 cycles. Results ① The tumor volume of all patients were reduced to varying degrees, soft cervical tissue, gap widening, reduce vaginal congestion. ② Complete remission in 4 cases (11.76%), partial remission in 23 cases (67.65%), stable disease in 7 cases (20.59%). 31 patients underwent extensive hysterectomy, pelvic lymphadenectomy and bilateral accessory resection after chemotherapy. Three patients underwent extensive hysterectomy, pelvic lymph node dissection, ovarian suspension, surgery The rate is 100%. All patients had some degree of chemotherapy during chemotherapy side effects, mainly bone marrow suppression, digestive tract reactions, hair loss, etc., according to the WHO classification standard chemotherapy side effects are ≤ Ⅰ level. Conclusion paclitaxel combined with carboplatin in the treatment of locally advanced cervical cancer is effective and safe.