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阿朴西林(Aspoxicillin)系日本田边制药公司研制的合成青霉素类抗生素,在青霉素母核的6位侧链上有N~4-甲基-D-天冬酰胺,对革兰氏阳性菌、阴性菌均呈杀菌性抗菌活性。向组织、体液的较运良好,在生物体内几乎不被代谢,而经肾排泄,且毒性低。临床试验表明,本品对呼吸系统感染、外科感染、细菌性心内膜炎、败血症、中耳炎及颚炎等有效。本品1987年3月得到承认,同年8月6日上市。
Aspoxicillin is a synthetic penicillin antibiotic developed by Tanabe Pharmaceutical Co., Ltd. in Japan. N-4-Methyl-D-asparagine is present on the 6th side chain of penicillin mother nucleus. Gram positive bacteria, Negative bacteria showed bactericidal antibacterial activity. To the organization, body fluids more good transport in the body almost no metabolism, but by the renal excretion, and low toxicity. Clinical trials show that the product of respiratory infections, surgical infections, bacterial endocarditis, sepsis, otitis media and jaw inflammation and so effective. This product was recognized in March 1987, the same year August 6 listed.