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目的研究大鼠染锰后对其子代新生鼠肝组织内微量元素的影响。方法 :将妊娠雌性大鼠随机分为 4组 ,腹腔注射氯化锰 ,剂量分别为 0、7.5、1 5和 30 mg/kg,待其自然分娩后采用原子吸收光谱法测定子代新生鼠肝组织内微量元素锰、铜、锌和铁含量。结果 :与对照组相比 ,实验各组肝组织内锰含量明显增高 ( P<0 .0 1 ) ;锌含量则低于对照组 ( P<0 .0 5,P<0 .0 1 ) ;实验各组铜含量与对照组间差异无显著性 ( P>0 .0 5) ;1 5mg/kg和 30 mg/kg组铁含量高于对照组 ( P<0 .0 5,P<0 .0 1 )。结论 :大鼠孕期染锰 ,使其新生鼠肝组织内锰、锌、铁等微量元素的含量发生明显变化 ,影响了锰、锌、铁在体内的代谢 ,从而对其子代的生长发育可能产生不利影响
Objective To study the effect of manganese on the trace elements in the liver tissue of offspring neonatal rats. Methods: Pregnant female rats were randomly divided into 4 groups, intraperitoneal injection of manganese chloride at doses of 0, 7.5, 15 and 30 mg / kg respectively. After natural delivery, the offspring of neonatal rat liver were determined by atomic absorption spectrometry Tissue trace elements manganese, copper, zinc and iron content. Results: Compared with the control group, the contents of manganese in the liver of each experimental group were significantly increased (P <0.01); the content of zinc in the experimental group was lower than that of the control group (P <0.05, P <0.01); There was no significant difference between the experimental group and the control group (P> 0.05). The content of iron in the groups of 15 mg / kg and 30 mg / kg was higher than that of the control group (P <0.05, P <0.05). 0 1). Conclusion: In pregnant rats, the content of manganese, zinc, iron and other trace elements in the liver tissue of newborn rats changed significantly after they were infected with manganese, which affected the metabolism of manganese, zinc and iron in vivo, which might affect the growth and development of their offspring Have a negative impact