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鼻咽癌患者外周淋巴细胞经紫外线或化学致癌剂N-甲基-N’-硝基-N-亚硝基胍(MNNG)处理后,其非程序DNA合成(UDS)值比健康人的为低;三个鼻咽癌高发家系中,鼻咽癌患者及其血缘亲属的UDS值亦比对照者的为低,而其非血缘亲属与对照者之间的UDS值则无统计学的显著差异。这结果表明鼻咽癌患者淋巴细胞DNA损伤后的修复功能有缺陷,这一缺陷可能与遗传易感因素有关。
Non-program DNA synthesis (UDS) values of peripheral lymphocytes from patients with nasopharyngeal carcinoma after treatment with ultraviolet or chemical carcinogen N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) were higher than those of healthy people. Low; the UDS values of nasopharyngeal carcinoma patients and their blood relatives were lower in three high-risk nasopharyngeal carcinoma families than in controls, while the UDS values between non-blood relatives and controls were not statistically significant. difference. This result suggests that the repair function of lymphocyte DNA damage in patients with nasopharyngeal carcinoma is defective, and this defect may be related to genetic susceptibility factors.