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目的 调查西安地区职业献血员及血透患者和不同类型肝炎患者ＴＴＶ（ｔｒａｎｓｆｕｓｉｏｎ ｔｒａｎｓｍｉｔｔｅｄ ｖｉｒｕｓ） 感染状况．方法 在ＴＴＶ ＯＲＦ１ 区设计两套引物，用巢式聚合酶链反应（ｎｅｓｔｅｄＰＣＲ） ，检测我院有偿献血员２０８ 例，血液透析患者３０例及我院住院的非肝炎患者１２８ 例，不同类型肝炎患者１４７ 例ＴＴＶ 感染率．结果 西安地区职业献血员ＴＴＶ 阳性率１６－８ ％ （３５／ ２０８） ，血透患者ＴＴＶ 阳性率４７ ％ （１４／ ３０） ，非肝炎患者ＴＴＶ 阳性率２－２ ％ （３／ １２８ ） ， 前两组与后一组统计处理（χ２ ＝ １４－２６ ）（χ２ ＝ ４７－２８） （χ２ ＝ ４９－４８ ，Ｐ＜ ０－００１） ，整体比较（χ２ ＝ ４１－８８６ ，Ｐ＜ ０－００１） ． 非甲－ 戊型肝炎６０ ％ （９／ １５） ， 庚型肝炎组为５０ ％ （６／ １２） ，乙型肝炎组为２６ ％ （２１／ ８０） ，丙型肝炎组为１９ ％（６／ ３１） ，甲型肝炎组０（０／ ９） ．结论 西安地区与血液紧密接触人群中存在严重的ＴＴＶ 感染，其分布支持ＴＴＶ 以输血传播为主特性． 不同类型肝炎患者中，除甲肝外均有ＴＴＶ 重叠感染，其中以非甲－ 非戊型肝炎和庚型肝?
Objective To investigate the status of transfusion transmitted virus (TTV) in professional blood donors and hemodialysis patients and patients with different types of hepatitis in Xi’an. Methods Two sets of primers were designed in the ORF1 region of TTV. Nested PCR was used to detect 208 paid blood donors in our hospital, 30 hemodialysis patients and 128 non-hepatitis patients hospitalized in our hospital. 147 cases of hepatitis patients TTV infection rate. Results The positive rate of TTV in professional blood donors in Xi’an was 16-8% (35/208), the positive rate of TTV in hemodialysis patients was 47% (14/30), and the positive rate of TTV in non-hepatitis patients was 2-2% (3/128) The two groups were statistically different from the latter group (χ2 = 14-26) (χ2 = 47-28) (χ2 = 49-48, P <0-001) ). Hepatic hepatitis group was 50% (6/12), hepatitis B group was 26% (21/80), hepatitis C group was 19% (6/12) 31), Hepatitis A group 0 (0/9). Conclusions There is a serious TTV infection in the close contact with blood in Xi’an and its distribution supports the main feature of TTV transfusion. Different types of hepatitis patients, in addition to hepatitis A have TTV overlap infection, which non-A - non-hepatitis E and G-type liver?