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目的:探讨肠炎清对受损肠黏膜肠道通透性和D-乳酸水平的干预作用。方法:将60例结肠黏膜损伤患者,随机分为2组,每组30例。治疗组用本院制剂肠炎清治疗;对照组用美沙拉嗪肠溶片治疗。疗程均为6周。另设30例门诊健康体检者作为正常对照组。观察患者治疗前后中医主要症状积分及D-乳酸水平的变化。结果:2组治疗后中医主要症状积分均有显著下降,与治疗前比较,差异均有非常显著性意义(P<0.01);2组治疗后比较,差异有显著性意义(P<0.05),治疗组改善优于对照组。2组治疗后D-乳酸均有下降,与治疗前比较,差异均有非常显著性意义(P<0.01);2组治疗后比较,差异无显著性意义(P>0.05)。治疗组治疗后与正常对照组比较,差异无显著性意义(P>0.05),说明D-乳酸接近正常水平。对照组治疗后与正常对照组比较,差异有显著性意义(P<0.05),说明对照组治疗后D-乳酸仍高于正常水平范围。结论:肠炎清能够有效减轻临床症状,修复受损肠黏膜,降低D-乳酸水平,从而降低肠道通透性,改善肠黏膜屏障功能。
Objective: To investigate the effect of Changyanqing on intestinal permeability and D-lactate level in damaged intestinal mucosa. Methods: 60 patients with colonic mucosal injury were randomly divided into 2 groups, 30 in each group. The treatment group was treated with Changyanqing, a preparation of this hospital; the control group was treated with mesalazine-coated enteric-coated tablets. The course of treatment is 6 weeks. Another 30 outpatient health examinations were used as normal controls. Observe the changes of the scores of major symptoms and D-lactate levels in the traditional Chinese medicine before and after treatment. Results: The scores of the main symptom scores of Chinese medicine after treatment in both groups decreased significantly. Compared with before treatment, the differences between the two groups were very significant (P<0.01). There was a significant difference between the two groups after treatment (P<0.05). The treatment group improved better than the control group. D-lactate was decreased in both groups after treatment, and there was a significant difference between the two groups before treatment (P<0.01). There was no significant difference between the two groups after treatment (P>0.05). There was no significant difference between the treatment group and the normal control group after treatment (P>0.05), indicating that D-lactic acid was close to normal level. The difference between the control group and the normal control group after treatment was significant (P<0.05), indicating that the D-lactic acid in the control group was still higher than the normal range after treatment. Conclusion: Changyanqing can effectively reduce the clinical symptoms, repair the damaged intestinal mucosa, reduce the level of D-lactic acid, thereby reducing the intestinal permeability and improving the intestinal mucosal barrier function.